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Article

Threshold-dominated regulation hides genetic variation in gene expression networks.

BMC systems biology - 6 Dec 2007

Gjuvsland Arne B, Plahte Erik, Omholt Stig W

Abstract excerpt

BACKGROUND: In dynamical models with feedback and sigmoidal response functions, some or all variables have thresholds around which they regulate themselves or other variables. A mathematical analysis has shown that when the dose-response functions approach binary or on/off responses, any variable with an equilibrium value close to one of its thresholds is very robust to parameter perturbations of a homeostatic...

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Identifiers

PMID: 18062810
DOI: 10.1186/1752-0509-1-57
PMCID: PMC2238762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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