Article

Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway

2020-02-17

Abstract excerpt

Activating mutations in RAS are present in ∼30% of human tumors, and the resulting aberrations in ERK/MAPK signaling play a central role in oncogenesis. However, the form of these signaling changes is uncertain, with activating RAS mutants linked to both increased and decreased ERK activation in vivo . Rationally targeting the kinase activity of this pathway requires clarification of the quantitative effects of R...

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Literature Corpus work: 2ab7b7c7-3c27-58e6-afc8-e39221bd4dc4
DOI: 10.1101/2020.02.17.952093

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