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Article

Temporal association of HLA-B81:01- and HLA-B39:10-mediated HIV-1 p24 sequence evolution with disease progression.

Journal of virology - 1 Nov 2012

Ntale R S, Chopera D R, Ngandu N K, Assis de Rosa D, Zembe L, Gamieldien H, Mlotshwa M, Werner L, Woodman Z, Mlisana K, Abdool Karim S, Gray C M, Williamson C

Abstract excerpt

HLA-B*81:01 and HLA-B*39:10 alleles have been associated with viremic control in HIV-1 subtype C infection. Both alleles restrict the TL9 epitope in p24 Gag, and cytotoxic-T-lymphocyte (CTL)-mediated escape mutations in this epitope have been associated with an in vitro fitness cost to the virus. We investigated the timing and impact of mutations in the TL9 epitope on disease progression in five B*81:01- and two...

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Identifiers

PMID: 22933291
DOI: 10.1128/JVI.00539-12
PMCID: PMC3486481

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Source receipt: pubmed, retrieved 7 Sept 2026.

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