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Article

Characterization of macrozoospermia-associated AURKC mutations in a mammalian meiotic system.

Human molecular genetics - 1 Jul 2016

Fellmeth Jessica E, Ghanaim Elena M, Schindler Karen

Abstract excerpt

Aneuploidy is the leading genetic abnormality that leads to miscarriage, and it is caused by a failure of accurate chromosome segregation during gametogenesis or early embryonic divisions. Aurora kinase C (AURKC) is essential for formation of euploid sperm in humans because mutations in AURKC are correlated with macrozoospermia and these sperm are tetraploid. These mutations are currently the most frequent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27106102
DOI: 10.1093/hmg/ddw128

Genes

AURKC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of macrozoospermia-associated AURKC mutations in a mammalian meiotic system.PMID 27106102Read ↗

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