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Aurora B Overexpression Causes Aneuploidy and p21 Cip1 Repression during Tumor Development

3 Aug 2015

Abstract excerpt

Aurora kinase B, one of the three members of the mammalian Aurora kinase family, is the catalytic component of the chromosomal passenger complex, an essential regulator of chromosome segregation in mitosis. Aurora B is overexpressed in human tumors although whether this kinase may function as an oncogene in vivo is not established. Here, we report a new mouse model in which expression of the endogenous Aurkb...

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PMID: 26240282
DOI: 10.1128/mcb.01286-14

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