Article
The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes.
Journal of cell science - 15 Dec 2010
Sharif Bedra, Na Jie, Lykke-Hartmann Karin, McLaughlin Stephen H, Laue Ernest, Glover David M, Zernicka-Goetz Magdalena
Abstract excerpt
The existence of two forms of the chromosome passenger complex (CPC) in the mammalian oocyte has meant that its role in female meiosis has remained unclear. Here we use loss- and gain-of function approaches to assess the meiotic functions of one of the shared components of these complexes, INCENP, and of the variable kinase subunits, Aurora B or Aurora C. We show that either the depletion of INCENP or the...
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