Article
Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk prediction.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2011
Crooke Philip S, Justenhoven Christina, Brauch Hiltrud, Dawling Sheila, Roodi Nady, Higginbotham Kathryn S P, Plummer W Dale, Schuyler Peggy A, Sanders Melinda E, Page David L, Smith Jeffrey R, Dupont William D, Parl Fritz F
Abstract excerpt
BACKGROUND: Current models of breast cancer risk prediction do not directly reflect mammary estrogen metabolism or genetic variability in exposure to carcinogenic estrogen metabolites. METHODS: We developed a model that simulates the kinetic effect of genetic variants of the enzymes CYP1A1, CYP1B1, and COMT on the production of the main carcinogenic estrogen metabolite, 4-hydroxyestradiol (4-OHE(2)), expressed as...
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