Article
Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility.
PLoS genetics - 1 Jul 2010
Low Yen Ling, Li Yuqing, Humphreys Keith, Thalamuthu Anbupalam, Li Yi, Darabi Hatef, Wedrén Sara, Bonnard Carine, Czene Kamila, Iles Mark M, Heikkinen Tuomas, Aittomäki Kristiina, Blomqvist Carl, Nevanlinna Heli, Hall Per, Liu Edison T, Liu Jianjun
Abstract excerpt
Despite the central role of estrogen exposure in breast and endometrial cancer development and numerous studies of genes in the estrogen metabolic pathway, polymorphisms within the pathway have not been consistently associated with these cancers. We posit that this is due to the complexity of multiple weak genetic effects within the metabolic pathway that can only be effectively detected through multi-variant...
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