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Article

Joint relative risks for estrogen receptor-positive breast cancer from a clinical model, polygenic risk score, and sex hormones.

Breast cancer research and treatment - 1 Nov 2017

Shieh Yiwey, Hu Donglei, Ma Lin, Huntsman Scott, Gard Charlotte C, Leung Jessica W T, Tice Jeffrey A, Ziv Elad, Kerlikowske Karla, Cummings Steven R

Abstract excerpt

BACKGROUND: Models that predict the risk of estrogen receptor (ER)-positive breast cancers may improve our ability to target chemoprevention. We investigated the contributions of sex hormones to the discrimination of the Breast Cancer Surveillance Consortium (BCSC) risk model and a polygenic risk score comprised of 83 single nucleotide polymorphisms. METHODS: We conducted a nested case-control study of 110 women...

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Identifiers

PMID: 28791495
DOI: 10.1007/s10549-017-4430-2
PMCID: PMC5669824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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