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Discovery of breast cancer risk genes and establishment of a prediction model based on estrogen metabolism regulation.

BMC cancer - 25 Feb 2021

Zhao Feng, Hao Zhixiang, Zhong Yanan, Xu Yinxue, Guo Meng, Zhang Bei, Yin Xiaoxing, Li Ying, Zhou Xueyan

Abstract excerpt

BACKGROUND: Multiple common variants identified by genome-wide association studies have shown limited evidence of the risk of breast cancer in Chinese individuals. In this study, we aimed to uncover the relationship between estrogen levels and the genetic polymorphism of estrogen metabolism-related enzymes in breast cancer (BC) and establish a risk prediction model composed of estrogen-metabolizing enzyme genes...

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Identifiers

PMID: 33632172
DOI: 10.1186/s12885-021-07896-4
PMCID: PMC7905915

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