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Article

Application of pyrosequencing technique for improved detection of K-Ras mutation in formalin-fixed and paraffin-embedded prostate carcinoma tissues in Chinese patients.

Clinica chimica acta; international journal of clinical chemistry - 9 Oct 2012

Sha Jianjun, Liang Guoqing, Pan Jiahua, Xuan Hanqing, Ping Ping, Li Dong, Bo Juanjie, Liu Dongming, Shen Wei, Liu Weiwei, Huang Yiran

Abstract excerpt

BACKGROUND: The purpose of this study was to comparatively evaluate the efficacy of pyrosequencing (PS) and Sanger sequencing (SS) methods for detecting K-Ras codon 12 and 13 mutations in formalin-fixed paraffin-embedded (FFPE) prostate cancer (PCa) samples from Chinese patients. METHODS: The cancer cell lines, including the LS174T G12D mutant (GGT to GAT) and the COLO320 wild-type, were tested to determine the...

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PMID: 22732508
DOI: 10.1016/j.cca.2012.06.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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