Article
KRAS and BRAF mutations in prostate carcinomas of Chinese patients.
Cancer genetics and cytogenetics - 1 Apr 2010
Shen Yanying, Lu Yachao, Yin Xiaolu, Zhu Guanshan, Zhu Jianshan
Abstract excerpt
Aberrance in the RAS/RAF/MEK/MAPK pathway is reportedly important in many tumor types, including prostate carcinoma. Continuous activation of the pathway can be caused by mutations of upstream targets such as KRAS and BRAF. However, rates of KRAS and BRAF mutations in prostate carcinoma are reported to vary in different populations. To date, there has been no such report in Chinese patients. In this study, we...
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