Herpes simplex virus type 1 encodes two Fc receptors which have different binding characteristics for monomeric immunoglobulin G (IgG) and IgG complexes.

Abstract excerpt

Two herpes simplex virus type 1 glycoproteins, gE and gI, have been shown to form a complex that binds the Fc domain of immunoglobulin G (IgG). We demonstrate that this complex is required for the binding of monomeric nonimmune IgG but that gE alone is sufficient for binding polymeric IgG in the form of IgG complexes. Evidence that gE but not gI is required for binding IgG complexes is as follows. IgG complexes...

Topics

• Animals
• Antibodies, Monoclonal
• Antigens, Differentiation
• Cell Line
• Cells, Cultured
• Cloning, Molecular
• DNA, Viral
• Endothelium, Vascular
• Flow Cytometry
• Genetic Complementation Test
• Humans