Article
In vivo immune evasion mediated by the herpes simplex virus type 1 immunoglobulin G Fc receptor.
Journal of virology - 1 Jul 1998
Nagashunmugam T, Lubinski J, Wang L, Goldstein L T, Weeks B S, Sundaresan P, Kang E H, Dubin G, Friedman H M
Abstract excerpt
Herpes simplex virus (HSV) glycoproteins gE and gI form an immunoglobulin G (IgG) Fc receptor (FcgammaR) that binds the Fc domain of human anti-HSV IgG and inhibits Fc-mediated immune functions in vitro. gE or gI deletion mutant viruses are avirulent, probably because gE and gI are also involved in cell-to-cell spread. In an effort to modify FcgammaR activity without affecting other gE functions, we constructed a...
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