Article
In vivo immune evasion mediated by the herpes simplex virus type 1 immunoglobulin G Fc receptor.
Journal of virology - 1 Jul 1998
Nagashunmugam T, Lubinski J, Wang L, Goldstein L T, Weeks B S, Sundaresan P, Kang E H, Dubin G, Friedman H M
Abstract excerpt
Herpes simplex virus (HSV) glycoproteins gE and gI form an immunoglobulin G (IgG) Fc receptor (FcgammaR) that binds the Fc domain of human anti-HSV IgG and inhibits Fc-mediated immune functions in vitro. gE or gI deletion mutant viruses are avirulent, probably because gE and gI are also involved...
Topics
- Animals
- Chlorocebus aethiops
- Female
- Herpes Simplex
- Herpesvirus 1, Human
- Humans
- Immunization, Passive
- Immunoglobulin G
- Mice
- Mice, Inbred BALB C
- Mutation
- Receptors, IgG
- Vero Cells
- Viral Envelope Proteins