Article
Immune evasion properties of herpes simplex virus type 1 glycoprotein gC.
Journal of virology - 1 Jul 1996
Friedman H M, Wang L, Fishman N O, Lambris J D, Eisenberg R J, Cohen G H, Lubinski J
Abstract excerpt
Herpes simplex virus type I (HSV-1) glycoprotein gC binds complement component C3b, and purified gC inhibits complement activation. Two HSV strains carrying mutations in the gC gene which rendered them unable to bind C3b were compared with wild-type and marker-rescued viruses to evaluate the role...
Topics
- Animals
- Antibodies, Viral
- Base Sequence
- Blotting, Southern
- Blotting, Western
- Chlorocebus aethiops
- Complement C3b
- Complement Pathway, Classical
- DNA Primers
- Genotype
- Herpesvirus 1, Human
- Humans
- Molecular Sequence Data
- Mutation
- Neutralization Tests
- Phenotype
- Time Factors
- Tumor Cells, Cultured