Article
Two distinct regions of FC gamma RI initiate separate signalling pathways involved in endocytosis and phagocytosis.
The EMBO journal - 1 Feb 1995
Davis W, Harrison P T, Hutchinson M J, Allen J M
Abstract excerpt
Cross-linking of the high affinity receptor for IgG, Fc gamma RI, can result in both endocytosis of immune complexes and phagocytosis of opsonized particles in myeloid cells, although the cytoplasmic domain of the receptor lacks the tyrosine activation motif which has been implicated in signal tr...
Topics
- Animals
- Antigen-Antibody Complex
- Base Sequence
- Cell Membrane
- Cell Polarity
- Cells, Cultured
- Endocytosis
- Humans
- Ligands
- Mice
- Molecular Sequence Data
- Mutation
- Opsonin Proteins
- Phagocytosis
- Protein Conformation
- Receptor Protein-Tyrosine Kinases
- Receptors, IgG
- Recombinant Fusion Proteins