Article
Two distinct regions of FC gamma RI initiate separate signalling pathways involved in endocytosis and phagocytosis.
The EMBO journal - 1 Feb 1995
Davis W, Harrison P T, Hutchinson M J, Allen J M
Abstract excerpt
Cross-linking of the high affinity receptor for IgG, Fc gamma RI, can result in both endocytosis of immune complexes and phagocytosis of opsonized particles in myeloid cells, although the cytoplasmic domain of the receptor lacks the tyrosine activation motif which has been implicated in signal transduction triggered by cross-linking of other Fc receptors. To identify the structural determinants of Fc gamma...
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