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Article

Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus.

Journal of virology - 1 Nov 1995

Dingwell K S, Doering L C, Johnson D C

Abstract excerpt

Two herpes simplex virus (HSV) glycoproteins E and I (gE and gI) form a heterooligomer which acts as an Fc receptor and also facilitates cell-to-cell spread of virus in epithelial tissues and between certain cultured cells. By contrast, gE-gI is not required for infection of cells by extracellular virus. HSV glycoproteins gD and gJ are encoded by neighboring genes, and gD is required for both virus entry into...

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Identifiers

PMID: 7474128
DOI: 10.1128/JVI.69.11.7087-7098.1995
PMCID: PMC189628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus.PMID 7474128Read ↗

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Herpes simplex virus gE/gI extracellular domains promote axonal transport and spread from neurons to epithelial cells.Semantic proximity Read ↗

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A herpes simplex virus 1 (McKrae) mutant lacking the glycoprotein K gene is unable to infect via neuronal axons and egress from neuronal cell bodies.Semantic proximity Read ↗

Induction of Rod-Shaped Structures by Herpes Simplex Virus Glycoprotein I.Semantic proximity Read ↗

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Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia.Semantic proximity Read ↗

Aberrant infection and persistence of varicella-zoster virus in human dorsal root ganglia <i>in vivo</i> in the absence of glycoprotein ISemantic proximity Read ↗

An analysis of the in vitro and in vivo phenotypes of mutants of herpes simplex virus type 1 lacking glycoproteins gG, gE, gI or the putative gJ.Semantic proximity Read ↗

Varicella-Zoster Virus Glycoprotein E Is a Critical Determinant of Virulence in the SCID Mouse-Human Model of NeuropathogenesisSemantic proximity Read ↗

The role of herpes simplex virus glycoproteins in the virus replication cycle.Semantic proximity Read ↗

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