Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus.

doi:10.1128/JVI.69.11.7087-7098.1995

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Article

Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus.

Journal of virology - 1 Nov 1995

Dingwell K S, Doering L C, Johnson D C

Abstract excerpt

Two herpes simplex virus (HSV) glycoproteins E and I (gE and gI) form a heterooligomer which acts as an Fc receptor and also facilitates cell-to-cell spread of virus in epithelial tissues and between certain cultured cells. By contrast, gE-gI is not required for infection of cells by extracellular virus. HSV glycoproteins gD and gJ are encoded by neighboring genes, and gD is required for both virus entry into...

Topics

Animals
Cells, Cultured
Chlorocebus aethiops
Female
Genotype
Herpesvirus 1, Human
Kinetics
Mutation
Neurons
Phenotype
Rats
Rats, Wistar

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retina

Time Factors

Trigeminal Ganglion

Vero Cells

Viral Envelope Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 7474128
DOI: 10.1128/JVI.69.11.7087-7098.1995
PMCID: PMC189628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7474128-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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