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Article

Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes.

AIDS research and therapy - 12 Sept 2017

Grant Michael, Larijani Mani

Abstract excerpt

APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive complexes and filtration of mutations during viral life cycle. We hypothesized that the impact of...

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Identifiers

PMID: 28893290
DOI: 10.1186/s12981-017-0173-8
PMCID: PMC5594601

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