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Article

Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.

Cell host & microbe - 12 Apr 2017

Pollack Ross A, Jones R Brad, Pertea Mihaela, Bruner Katherine M, Martin Alyssa R, Thomas Allison S, Capoferri Adam A, Beg Subul A, Huang Szu-Han, Karandish Sara, Hao Haiping, Halper-Stromberg Eitan, Yong Patrick C, Kovacs Colin, Benko Erika, Siliciano Robert F, Ho Ya-Chi

Abstract excerpt

Despite antiretroviral therapy, HIV-1 persists in memory CD4+ T cells, creating a barrier to cure. The majority of HIV-1 proviruses are defective and considered clinically irrelevant. Using cells from HIV-1-infected individuals and reconstructed patient-derived defective proviruses, we show that defective proviruses can be transcribed into RNAs that are spliced and translated. Proviruses with defective major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28407485
DOI: 10.1016/j.chom.2017.03.008
PMCID: PMC5433942

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