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Article

Stabilization of the tumor suppressor p53 during cellular transformation by simian virus 40: influence of viral and cellular factors and biological consequences.

Journal of virology - 1 May 1994

Tiemann F, Deppert W

Abstract excerpt

To understand the process and biological significance of metabolic stabilization of p53 during simian virus 40 (SV40)-induced cellular transformation, we analyzed cellular and viral parameters involved in this process. We demonstrate that neither large T expression as such nor the cellular phenotype (normal versus transformed) markedly influence the stability of p53 complexed to large T in SV40 abortively...

Topics

3T3 Cells
Animals
Antigens, Viral, Tumor
Cell Transformation, Neoplastic
Cell Transformation, Viral
Fibroblasts
Mice
Mice, Inbred C57BL
Phenotype
Rats
Simian virus 40

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

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Identifiers

PMID: 8151757
DOI: 10.1128/JVI.68.5.2869-2878.1994
PMCID: PMC236775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8151757-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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