Article
Stable T-p53 complexes are not required for replication of simian virus 40 in culture or for enhanced phosphorylation of T antigen and p53.
Journal of virology - 1 Apr 1991
Lin J Y, Simmons D T
Abstract excerpt
We generated a number of simian virus 40 (SV40) mutants with single amino acid substitutions in T antigen between residues 388 and 411. All but one mutant (398LV) replicated like wild-type SV40 and gave rise to normal-size plaques. Three different mutations at residue 402 (Asp to Glu, Asn, or His...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antigens, Viral, Tumor
- Cells, Cultured
- Epitopes
- Haplorhini
- Humans
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Retroviridae Infections
- Simian virus 40
- Tumor Suppressor Protein p53
- Virus Replication