Article
Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.
The EMBO journal - 1 May 1990
Gannon J V, Greaves R, Iggo R, Lane D P
Abstract excerpt
Point mutations in the p53 gene are the most frequently identified genetic change in human cancer. They convert murine p53 from a tumour suppressor gene into a dominant transforming oncogene able to immortalize primary cells and bring about full transformation in combination with an activated ras...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Polyomavirus Transforming
- Cell Line, Transformed
- Epitopes
- Immunoenzyme Techniques
- Macromolecular Substances
- Mice
- Models, Biological
- Mutation
- Oncogene Proteins
- Phosphoproteins
- Precipitin Tests
- Protein Binding
- Protein Conformation
- Protein Denaturation
- Structure-Activity Relationship
- Tumor Suppressor Protein p53