Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

The EMBO journal - 1 May 1990

Gannon J V, Greaves R, Iggo R, Lane D P

Abstract excerpt

Point mutations in the p53 gene are the most frequently identified genetic change in human cancer. They convert murine p53 from a tumour suppressor gene into a dominant transforming oncogene able to immortalize primary cells and bring about full transformation in combination with an activated ras gene. In both the human and murine systems the mutations lie in regions of p53 conserved from man to Xenopus. We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Epitopes
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Biological

Share to Mutation

Share to Protein Binding

Share to Protein Conformation

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 1691710
DOI: 10.1002/j.1460-2075.1990.tb08279.x
PMCID: PMC551855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.PMID 1691710Read ↗

Mutations in p53 produce a common conformational effect that can be detected with a panel of monoclonal antibodies directed toward the central part of the p53 protein.Semantic proximity Read ↗

A PAb240+ conformation of wild type p53 binds DNA.Semantic proximity Read ↗

p53 mutants with changes in conserved region II: three classes with differing antibody reactivity, SV40 T antigen binding and ability to inhibit transformation of rat cells.Semantic proximity Read ↗

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.Semantic proximity Read ↗

The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein.Semantic proximity Read ↗

Hemi- or homozygosity: a requirement for some but not other p53 mutant proteins to accumulate and exert a pathogenetic effect.Semantic proximity Read ↗

A new set of monoclonal antibodies directed to proline-rich and central regions of p53.Semantic proximity Read ↗

Altered conformation of the p53 protein in myeloid leukemia cells and mitogen-stimulated normal blood cells.Semantic proximity Read ↗

Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53.Semantic proximity Read ↗

Effect of mutation and conformation on the function of p53 in colorectal cancer.Semantic proximity Read ↗

Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.Semantic proximity Read ↗

Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.