Article
Simian virus 40 large tumor antigen modulates the Raf signaling pathway.
The Journal of biological chemistry - 27 Jul 2001
Grammatikakis N, Jaronczyk K, Siganou A, Vultur A, Brownell H L, Benzaquen M, Rausch C, Lapointe R, Gjoerup O, Roberts T M, Raptis L
Abstract excerpt
The large tumor antigen of simian virus 40 (SVLT) is a potent oncogene. Although inactivation of the p53 and pRb tumor suppressors has been causally linked to the transforming properties of SVLT, its exact mechanism of action remains undefined. Previous data indicated that Ras is activated in SVLT-expressing cells. In this report we show that SVLT also increases Raf kinase activity in both insect and mammalian...
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