Article
Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functions.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Sung P, Prakash S, Prakash L
Abstract excerpt
The RAD6 gene of Saccharomyces cerevisiae is required for DNA repair, DNA damage-induced mutagenesis, and sporulation. RAD6 protein is a ubiquitin-conjugating enzyme (E2) that has been shown to attach multiple molecules of ubiquitin to histones H2A and H2B. We have now examined whether the E2 act...
Topics
- Alanine
- Alleles
- Cysteine
- DNA Repair
- Dose-Response Relationship, Radiation
- Genes, Fungal
- Genotype
- Ligases
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins