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Article

RAD6 gene product of Saccharomyces cerevisiae requires a putative ubiquitin protein ligase (E3) for the ubiquitination of certain proteins.

The Journal of biological chemistry - 25 Aug 1991

Sharon G, Raboy B, Parag H A, Dimitrovsky D, Kulka R G

Abstract excerpt

The RAD6 (UBC2) gene of Saccharomyces cerevisiae which is involved in DNA repair, induced mutagenesis, and sporulation, encodes a ubiquitin-conjugating enzyme (E2). Since the RAD6 gene product can transfer ubiquitin directly to histones in vitro without the participation of a ubiquitin protein ligase (E3), it has been suggested that in vivo it also acts by the unassisted conjugation of ubiquitin to histones or to...

Topics

Electrophoresis, Polyacrylamide Gel
Fungal Proteins
Genes, Fungal
Genetic Vectors
Ligases
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Substrate Specificity
Ubiquitin-Conjugating Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ubiquitin-Protein Ligases

Ubiquitins

Source

Identifiers

PMID: 1651925

Genes

CDC34

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1651925-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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RAD6 gene product of Saccharomyces cerevisiae requires a putative ubiquitin protein ligase (E3) for the ubiquitination of certain proteins.PMID 1651925Read ↗

Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functions.Semantic proximity Read ↗

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.Semantic proximity Read ↗

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Characterization of novel rad6/ubc2 ubiquitin-conjugating enzyme mutants in yeast.Semantic proximity Read ↗

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Yeast ubiquitin-conjugating enzymes involved in selective protein degradation are essential for cell viability.Semantic proximity Read ↗

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A site-directed approach for constructing temperature-sensitive ubiquitin-conjugating enzymes reveals a cell cycle function and growth function for RAD6.Semantic proximity Read ↗

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The rhp6+ gene of Schizosaccharomyces pombe: a structural and functional homolog of the RAD6 gene from the distantly related yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in RAD6, a yeast gene encoding a ubiquitin-conjugating enzyme, stimulate retrotransposition.Semantic proximity Read ↗

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6.Semantic proximity Read ↗

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