Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal.

Molecular microbiology - 1 May 1999

Raboy B, Marom A, Dor Y, Kulka R G

Abstract excerpt

The Saccharomyces cerevisiae RAD6 (UBC2 ) gene encodes a ubiquitin-conjugating enzyme that is involved in a wide range of cellular processes including DNA repair, sporulation and N-end rule protein degradation. Under mild heat stress conditions (37-38 degrees C) rad6 null and rad6-149 mutant cells are unable to grow. The molecular basis for this failure to grow is unknown. Here we show that the heat sensitivity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hot Temperature
Share to Cyclins
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Genes, cdc

Share to Interphase

Share to Ligases

Share to Ubiquitin-Conjugating Enzymes

Source

Identifiers

PMID: 10361277
DOI: 10.1046/j.1365-2958.1999.01389.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal.PMID 10361277Read ↗

A site-directed approach for constructing temperature-sensitive ubiquitin-conjugating enzymes reveals a cell cycle function and growth function for RAD6.Semantic proximity Read ↗

RAD6 gene is involved in heat shock induction of bleomycin resistance in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functions.Semantic proximity Read ↗

Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint.Semantic proximity Read ↗

Rad24 truncation, coupled with altered telomere structure, promotes cdc13-1 suppression in S. cerevisiae.Semantic proximity Read ↗

A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.Semantic proximity Read ↗

A yeast heat shock transcription factor (Hsf1) mutant is defective in both Hsc82/Hsp82 synthesis and spindle pole body duplication.Semantic proximity Read ↗

Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth.Semantic proximity Read ↗

Characterization of novel rad6/ubc2 ubiquitin-conjugating enzyme mutants in yeast.Semantic proximity Read ↗

Heat shock-mediated cell cycle blockage and G1 cyclin expression in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.Semantic proximity Read ↗

Increased ubiquitin expression suppresses the cell cycle defect associated with the yeast ubiquitin conjugating enzyme, CDC34 (UBC3). Evidence for a noncovalent interaction between CDC34 and ubiquitin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.