Article
Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.
The EMBO journal - 1 Feb 1990
Seufert W, Jentsch S
Abstract excerpt
Ubiquitin-conjugating enzymes catalyse the covalent attachment of ubiquitin to target proteins. Members of this enzyme family are involved in strikingly diverse cellular functions: UBC2 (RAD6) is central to DNA repair, UBC3 (CDC34) is involved in cell cycle control. We have cloned the genes for t...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Western
- Cell Cycle
- Genes, Fungal
- Hot Temperature
- Kinetics
- Ligases
- Molecular Sequence Data
- Multigene Family
- Mutation
- Oligonucleotide Probes
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription, Genetic
- Ubiquitin-Conjugating Enzymes
- Ubiquitins