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Article

Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability.

The Journal of biological chemistry - 1 Nov 2022

Shukla Prakash K, Sinha Dhiraj, Leng Andrew M, Bissell Jesse E, Thatipamula Shravya, Ganguly Rajarshi, Radmall Kaitlin S, Skalicky Jack J, Shrieve Dennis C, Chandrasekharan Mahesh B

Abstract excerpt

Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in transcription, genome maintenance, and proteostasis. The contributions of many conserved secondary structures of Rad6 and its human homologs UBE2A and UBE2B to their biological functions are not understood. A mutant RAD6 allele with a missense substitution at alanine-126 (A126) of helix-3 that causes defects in telomeric gene...

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Identifiers

PMID: 36162503
DOI: 10.1016/j.jbc.2022.102524
PMCID: PMC9630792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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