Article
The rhp6+ gene of Schizosaccharomyces pombe: a structural and functional homolog of the RAD6 gene from the distantly related yeast Saccharomyces cerevisiae.
The EMBO journal - 1 May 1990
Reynolds P, Koken M H, Hoeijmakers J H, Prakash S, Prakash L
Abstract excerpt
The RAD6 gene of Saccharomyces cerevisiae encodes a ubiquitin conjugating enzyme and is required for DNA repair, DNA-damage-induced mutagenesis and sporulation. Here, we show that RAD6 and the rhp6+ gene from the distantly related yeast Schizosaccharomyces pombe share a high degree of structural and functional homology. The predominantly acidic carboxyl-terminal 21 amino acids present in the RAD6 protein are...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA Repair
- DNA, Fungal
- Fungal Proteins
- Genetic Complementation Test
- Ligases
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae