Article
Elimination of the yeast RAD6 ubiquitin conjugase enhances base-pair transitions and G.C----T.A transversions as well as transposition of the Ty element: implications for the control of spontaneous mutation.
Genetics - 1 Feb 1992
Kang X L, Yadao F, Gietz R D, Kunz B A
Abstract excerpt
The RAD6 gene of the yeast Saccharomyces cerevisiae encodes an enzyme that conjugates ubiquitin to other proteins. Defects in RAD6 confer a mutator phenotype due, in part, to an increased rate of transposition of the yeast Ty element. To further delineate the role of protein ubiquitination in the control of spontaneous mutagenesis in yeast, we have characterized 202 mutations that arose spontaneously in the...
Topics
- Base Composition
- Base Sequence
- DNA Transposable Elements
- DNA, Fungal
- Fungal Proteins
- Genes, Fungal
- Ligases
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins