Article

Consequences of alanine-126 mutations in helix-3 on structure and functions of Rad6 E2 ubiquitin-conjugating enzymes

2021-10-12

Abstract excerpt

Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in transcription, genome maintenance and proteostasis. The contributions of many conserved secondary structures of Rad6 and its human homologs UBE2A and UBE2B to their biological functions are not understood. A mutant RAD6 allele with a missense substitution at alanine-126 (A126) of helix - 3 that causes defects in telomeric gene...

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Literature Corpus work: 96df58a3-3055-5526-b5c0-5b8564a63287
DOI: 10.1101/2021.10.12.464121

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Consequences of alanine-126 mutations in helix-3 on structure and functions of Rad6 E2 ubiquitin-conjugating enzymesDOI 10.1101/2021.10.12.464121Read

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