Article
Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen.
Oncogene - 1 Feb 1990
Theuring F, Götz W, Balling R, Korf H W, Schulze F, Herken R, Gruss P
Abstract excerpt
Transgenic mice which expressed SV40 large T-antigen under the control of the MSV enhancer and the SV40 promoter were generated. In animals containing an intact MSV enhancer, total lens cataracts and neuroectodermal brain tumors, originating in the pineal organ were observed. In contrast, 5' deletion of the MSV enhancer to a residual 53 bp resulted in a different spectrum of pathologies. Whilst lens cataracts...
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