Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen.

Oncogene - 1 Feb 1990

Theuring F, Götz W, Balling R, Korf H W, Schulze F, Herken R, Gruss P

Abstract excerpt

Transgenic mice which expressed SV40 large T-antigen under the control of the MSV enhancer and the SV40 promoter were generated. In animals containing an intact MSV enhancer, total lens cataracts and neuroectodermal brain tumors, originating in the pineal organ were observed. In contrast, 5' deletion of the MSV enhancer to a residual 53 bp resulted in a different spectrum of pathologies. Whilst lens cataracts...

Topics

Animals
Antigens, Polyomavirus Transforming
Brain Neoplasms
Chromosome Deletion
Enhancer Elements, Genetic
Eye
Eye Abnormalities
Female
Genotype
Male
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Moloney murine sarcoma virus

Neoplasms, Experimental

Phenotype

Pineal Gland

Sarcoma Viruses, Murine

Simian virus 40

Source

Open in PubMed

Identifiers

PMID: 2157185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2157185-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen.PMID 2157185Read ↗

Merkel Cell Polyomavirus Small T Antigen Is Oncogenic in Transgenic MiceSemantic proximity Read ↗

Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice.Semantic proximity Read ↗

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.Semantic proximity Read ↗

Increased transgene expression by the mouse tyrosinase enhancer is restricted to neural crest-derived pigment cells.Semantic proximity Read ↗

Timing of SV40 oncogene activation by site-specific recombination determines subsequent tumor progression during murine lens development.Semantic proximity Read ↗

Pituitary neoplasia induced by expression of human neurotropic polyomavirus, JCV, early genome in transgenic miceSemantic proximity Read ↗

SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice.Semantic proximity Read ↗

Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb.Semantic proximity Read ↗

Congenital nuclear cataracts and uveitis in HIV-transgenic mice.Semantic proximity Read ↗

Immortalization of neuro-endocrine cells from adrenal tumors arising in SV40 T-transgenic mice.Semantic proximity Read ↗

Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic mice.Semantic proximity Read ↗

Pigmented uveal tumours in a transgenic mouse model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.