Article
Pigmented uveal tumours in a transgenic mouse model.
The British journal of ophthalmology - 1 Aug 1998
Kramer T R, Powell M B, Wilson M M, Salvatore J, Grossniklaus H E
Abstract excerpt
AIMS/BACKGROUND: The authors have developed transgenic mouse strains at the Arizona Cancer Center using a tyrosinase promoter to target expression of the mutated T24 Ha-ras gene in melanin producing cells. Histopathology and electron microscopy (EM) were performed to characterise the intraocular tumours observed phenotypically. METHODS: Transgenic TPras mice (n = 8) and normal, age matched control mice (n = 6)...
Topics
- Animals
- Cell Division
- Disease Models, Animal
- Genes, ras
- Melanocytes
- Melanoma, Experimental
- Mice
- Mice, Transgenic
- Microscopy, Electron
- Mutation
- Pigment Epithelium of Eye