Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pigmented uveal tumours in a transgenic mouse model.

The British journal of ophthalmology - 1 Aug 1998

Kramer T R, Powell M B, Wilson M M, Salvatore J, Grossniklaus H E

Abstract excerpt

AIMS/BACKGROUND: The authors have developed transgenic mouse strains at the Arizona Cancer Center using a tyrosinase promoter to target expression of the mutated T24 Ha-ras gene in melanin producing cells. Histopathology and electron microscopy (EM) were performed to characterise the intraocular tumours observed phenotypically. METHODS: Transgenic TPras mice (n = 8) and normal, age matched control mice (n = 6)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Mice, Transgenic
Share to Microscopy, Electron

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Cell Division

Share to Disease Models, Animal

Share to Genes, ras

Share to Melanocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 9828784
DOI: 10.1136/bjo.82.8.953
PMCID: PMC1722710

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pigmented uveal tumours in a transgenic mouse model.PMID 9828784Read ↗

Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.Semantic proximity Read ↗

Induction of melanoma in TPras transgenic mice.Semantic proximity Read ↗

Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 HA‐ras gene regulated by a mouse tyrosinase promoterSemantic proximity Read ↗

Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61K on an INK4a-Deficient BackgroundSemantic proximity Read ↗

Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase.Semantic proximity Read ↗

Transgenic mouse model of malignant skin melanoma.Semantic proximity Read ↗

Expression of Cone-Photoreceptor–Specific Antigens in a Cell Line Derived from Retinal Tumors in Transgenic MiceSemantic proximity Read ↗

Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice.Semantic proximity Read ↗

Tg(Grm1) transgenic mice: A murine model that mimics spontaneous uveal melanoma in humans?Semantic proximity Read ↗

Ocular pathology in mice with a transgenic insertion at the microphthalmia locus.Semantic proximity Read ↗

Adenovirus E1A expression controlled by the red pigment promoter in transgenic mice: a model for developmental abnormalities of the eye.Semantic proximity Read ↗

Development of early melanocytic lesions in transgenic mice predisposed to melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.