Article
Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice.
Laboratory investigation; a journal of technical methods and pathology - 1 Jan 1994
Fung K M, Chikaraishi D M, Suri C, Theuring F, Messing A, Albert D M, Lee V M, Trojanowski J Q
Abstract excerpt
BACKGROUND: We compared the molecular phenotypes of central nervous system tumors arising in four different lines of transgenic mice (TGM) carrying the Simian virus 40 large T antigen driven by different promoters or enhancers. Two of the four lines developed primitive neuroectodermal tumors (PNETs) in the brain stem or pineal gland. A third TGM line developed retinoblastomas (a PNET-like tumor of the retina) as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.