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Article

SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice.

Journal of cancer research and clinical oncology - 1 Nov 2009

Zheng Hua-chuan, Nakamura Takafumi, Zheng Yang, Nakanishi Yuko, Tabuchi Yoshiaki, Uchiyama Akio, Takahashi Hiroyuki, Takano Yasuo

Abstract excerpt

PURPOSE: Simian Vacuolating Virus 40 (SV40) T antigen perturbed p53 and RB to cause cell malignant transformation. The purpose of this study was to identify the molecular changes during lens carcinogenesis and cancer progression induced by SV40 T antigen. METHODS: The different lens lesions of alpha A-crystallin/SV40 T antigen transgenic mice were examined using cDNA microarray, immunohistochemistry and TUNEL to...

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Source

Identifiers

PMID: 19466455
DOI: 10.1007/s00432-009-0599-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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