Congenital nuclear cataracts and uveitis in HIV-transgenic mice.

doi:10.1038/sj.eye.6700101

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Article

Congenital nuclear cataracts and uveitis in HIV-transgenic mice.

Eye (London, England) - 1 Mar 2002

Mozes M M, Bryant J L, Franks R, Chan C C, Kopp J B

Abstract excerpt

PURPOSE: Patients infected with HIV-1 develop ocular manifestations, some due to opportunistic infections and others attributed to the virus itself. Among the latter are retinal microvasculopathy and uveitis. We have analysed the ocular phenotype in HIV-transgenic mice. METHODS: We have studied T26 transgenic mice which bear a gag-pol deleted HIV-1 genome. Transgene RNA was detected by Northern analysis. Ocular...

Topics

Animals
Apoptosis
Blotting, Northern
Cataract
Fusion Proteins, gag-pol
Gene Deletion
HIV Infections
HIV-1
Immunohistochemistry
Mice
Mice, Transgenic
Phenotype
RNA, Viral
Transgenes
Uveitis
Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 11988819
DOI: 10.1038/sj.eye.6700101

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