Article
Timing of SV40 oncogene activation by site-specific recombination determines subsequent tumor progression during murine lens development.
Oncogene - 1 Dec 1993
Pichel J G, Lakso M, Westphal H
Abstract excerpt
We generated mice that carry copies of a dormant transgene encoding the SV40 tumor antigens. The transgenes are specifically targeted to the lens and contain features that render their expression dependent on the action of Cre, a site-specific bacteriophage DNA recombinase. Timing of oncogene activation was controlled by making Cre available either prior to, or coincident with, the onset of primary fiber...
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