Article
Timing of SV40 oncogene activation by site-specific recombination determines subsequent tumor progression during murine lens development.
Oncogene - 1 Dec 1993
Pichel J G, Lakso M, Westphal H
Abstract excerpt
We generated mice that carry copies of a dormant transgene encoding the SV40 tumor antigens. The transgenes are specifically targeted to the lens and contain features that render their expression dependent on the action of Cre, a site-specific bacteriophage DNA recombinase. Timing of oncogene act...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Cell Transformation, Neoplastic
- Crystallins
- DNA Nucleotidyltransferases
- Gene Expression Regulation, Viral
- Genes, Viral
- Immunohistochemistry
- Integrases
- Lens, Crystalline
- Mice
- Mice, Transgenic
- Oncogenes
- Organ Culture Techniques
- Phenotype
- Recombinases
- Recombination, Genetic