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Article

Proteolytic Shedding of Human Colony-Stimulating Factor 1 Receptor and its implication.

Journal of cellular and molecular medicine - 1 May 2021

Wei Yue, Ma Menghui, Lin Sheng, Li Xin, Shu Yue, Wang Ziwei, Zhou Yuhang, Hu Banglian, Cheng Baoying, Duan Shengshun, Huang Xiaohua, Xu Huaxi, Zhang Yun-Wu, Zheng Honghua

Abstract excerpt

Both Colony-stimulating factor 1 receptor (CSF1R) and triggering receptor expressed on myeloid cells-2 (TREM2) are trans-membrane receptors and are expressed in the brain primarily by microglia. Mutations in these two microglia-expressed genes associated with neurodegenerative disease have recently been grouped under the term "microgliopathy". Several literatures have indicated that CSF1R and TREM2 encounters a...

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Identifiers

PMID: 33783963
DOI: 10.1111/jcmm.16474
PMCID: PMC8093967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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