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Article

Regulation of P53 stability in p53 mutated human and mouse hepatoma cells.

International journal of cancer - 1 Apr 2007

Hailfinger Stephan, Jaworski Maike, Marx-Stoelting Philip, Wanke Ines, Schwarz Michael

Abstract excerpt

The tumor suppressor p53 is frequently mutated in cancer. We have investigated the regulation of P53 in p53 wild type mouse hepatoma cells (line 55.1c), in p53 heterozygeously mutated cells (56.1b) and in p53 defective cells (lines 56.1d, 70.4 and HUH7) under various experimental settings. The basal levels of P53 were low in 55.1c cells, but nuclear accumulation occurred upon UV-irradiation. Similarly,...

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Share to Carcinoma, Hepatocellular
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to Liver Neoplasms

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Cells, Cultured

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Source

Identifiers

PMID: 17205518
DOI: 10.1002/ijc.22519

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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