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Article

STAT-3 Inhibitors: State of the Art and New Horizons for Cancer Treatment

30 May 2011

Abstract excerpt

The signal transducers and activators of transcription (STATs) include a class of cytoplasmic signaling proteins whose role in the regulation of cell growth and survival is mediated by phosphorylation of a critical tyrosine residue within the STAT protein. This occurs in response to cytokines and growth factors modulating the expression of specific target genes. In particular, phosphorylation induces STAT:STAT...

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PMID: 21568920
DOI: 10.2174/092986711795843218

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