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Article

The potential and controversy of targeting STAT family members in cancer

9 Oct 2019

Abstract excerpt

The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of transcription factors that play a complex and essential role in the regulation of physiologic cell processes, such as proliferation, differentiation, apoptosis and angiogenesis, and serves to organize the epigenetic landscape of immune cells. To date, seven STAT genes have been identified in the human genome; STAT1, STAT2,...

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PMID: 31605750
DOI: 10.1016/j.semcancer.2019.10.002

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