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Strategies and Approaches of Targeting STAT3 for Cancer Treatment

5 Jan 2016

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates the expression of genes related to cell cycle, cell survival, and immune response associated with cancer progression and malignancy in a number of cancer types. Once activated, STAT3 forms a homodimer and translocates to the nucleus where it binds DNA promoting the translation of target genes associated with...

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PMID: 26730496
DOI: 10.1021/acschembio.5b00945

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