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Article

Overview of the STAT‑3 signaling pathway in cancer and the development of specific inhibitors (Review)

13 Feb 2020

Abstract excerpt

Signal transducer and activator of transcription (STAT) proteins represent novel therapeutic targets for the treatment of cancer. In particular, STAT‑3 serves critical roles in several cellular processes, including the cell cycle, cell proliferation, cellular apoptosis and tumorigenesis. Persistent activation of STAT‑3 has been reported in a variety of cancer types, and a poor prognosis of cancer may be...

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PMID: 32218808
DOI: 10.3892/ol.2020.11394

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