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Article

Direct Targeting Options for STAT3 and STAT5 in Cancer

3 Dec 2019

Abstract excerpt

Signal transducer and activator of transcription (STAT)3 and STAT5 are important transcription factors that are able to mediate or even drive cancer progression through hyperactivation or gain-of-function mutations. Mutated STAT3 is mainly associated with large granular lymphocytic T-cell leukemia, whereas mutated STAT5B is associated with T-cell prolymphocytic leukemia, T-cell acute lymphoblastic leukemia and γδ...

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PMID: 31817042
DOI: 10.3390/cancers11121930

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