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Novel activators and small-molecule inhibitors of STAT3 in cancer

1 Oct 2019

Abstract excerpt

Excessive activation of signal transducer and activator of transcription 3 (STAT3) signaling is observed in a subset of many cancers, making activated STAT3 a highly promising potential therapeutic target supported by multiple preclinical and clinical studies. However, early-phase clinical trials have produced mixed results with STAT3-targeted cancer therapies, revealing substantial complexity to targeting...

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PMID: 31677966
DOI: 10.1016/j.cytogfr.2019.10.005

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