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Article

STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers

24 Jul 2012

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) regulates many critical functions in human normal and malignant tissues, such as differentiation, proliferation, survival, angiogenesis and immune function. Constitutive activation of STAT3 is implicated in a wide range of human cancers. As such, STAT3 has been studied as a tumour therapeutic target. This review aimed principally to summarise the updated...

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PMID: 22842992
DOI: 10.3892/ijo.2012.1568

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