Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the Cytoplasmic and Nuclear Functions of Signal Transducers and Activators of Transcription 3 for Cancer Therapy

1 Oct 2007

Abstract excerpt

Signal transducers and activators of transcription (STAT) are a highly conserved family of transcription factors that are activated by phosphorylation in the cytoplasm, after which they translocate to the nucleus to regulate gene expression. Among the seven STATs, STAT3 is of particular interest due to its constitutive phosphorylation in a large proportion of human cancers and its ability to induce neoplastic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cancer-related Molecular Pathways
Share to Cytokine Signaling Pathways and Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17908954
DOI: 10.1158/1078-0432.ccr-06-2491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the Cytoplasmic and Nuclear Functions of Signal Transducers and Activators of Transcription 3 for Cancer TherapyPMID 17908954Read ↗

Critical analysis of the potential for targeting STAT3 in human malignancySemantic proximity Read ↗

Oncogenic STAT Transcription Factors as Targets for Cancer Therapy: Innovative Strategies and Clinical TranslationSemantic proximity Read ↗

STAT3 SIGNALING: Anticancer Strategies and ChallengesSemantic proximity Read ↗

STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancersSemantic proximity Read ↗

Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) proteinSemantic proximity Read ↗

Strategies and Approaches of Targeting STAT3 for Cancer TreatmentSemantic proximity Read ↗

Novel activators and small-molecule inhibitors of STAT3 in cancerSemantic proximity Read ↗

Overview of the STAT‑3 signaling pathway in cancer and the development of specific inhibitors (Review)Semantic proximity Read ↗

STAT-3 Inhibitors: State of the Art and New Horizons for Cancer TreatmentSemantic proximity Read ↗

STAT3 Signaling in CancerSemantic proximity Read ↗

STAT3 Target Genes Relevant to Human CancersSemantic proximity Read ↗

STAT proteins as novel targets for cancer drug discoverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.