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Article

STAT3 SIGNALING: Anticancer Strategies and Challenges

1 Feb 2011

Abstract excerpt

Multiple lines of evidence place STAT3 at a central node in the development, progression, and maintenance of many human tumors, and STAT3 has been validated as an anti-cancer target in several contexts. STAT3 modulates the transcription of a variety of genes involved in the regulation of critical functions, including cell differentiation, proliferation, apoptosis, angiogenesis, metastasis, and immune responses....

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PMID: 21441118
DOI: 10.1124/mi.11.1.4

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