Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature

Abstract excerpt

INTRODUCTION: The signal transducer and activator of transcription 3 (STAT3) is a transcription factor that plays a key role in normal cell growth and is constitutively activated in about 70% of solid and hematological cancers. Thus, the development of potent and selective inhibitors that target STAT3 is of interest especially in the cancer therapeutic area. AREAS COVERED: This review updates new patents claiming...

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