Selection of activating mutations of c-fms in FDC-P1 cells.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Selection of activating mutations of c-fms in FDC-P1 cells.

Oncogene - 5 Oct 1995

Glover H R, Baker D A, Celetti A, Dibb N J

Abstract excerpt

FDC-P1 haemopoietic cells were used to select mutations of c-fms that constitutively activate the receptor for macrophage-colony stimulating factor (M-CSF or CSF-1). One mutation changed Ser 929 to Gly within a Ser/Gly rich region of the C-terminal tail and a second changed a nearby, highly conserved Leu 926 for Pro. A third mutation (D802V) changed Asp 802 to Val within the alpha L12/beta 9 region of the...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Division
Cell Transformation, Neoplastic
DNA, Complementary
Hematopoietic Stem Cells
Humans
Macrophage Colony-Stimulating Factor
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligodeoxyribonucleotides

Phosphorylation

Protein-Tyrosine Kinases

Proto-Oncogene Proteins c-kit

Receptor, Macrophage Colony-Stimulating Factor

Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 7478556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7478556-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selection of activating mutations of c-fms in FDC-P1 cells.PMID 7478556Read ↗

Cell specific transformation by c-fms activating loop mutations is attributable to constitutive receptor degradation.Semantic proximity Read ↗

FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance.Semantic proximity Read ↗

Signal-response coupling mediated by the transduced colony-stimulating factor-1 receptor and its oncogenic fms variants in naive cells.Semantic proximity Read ↗

Synergy between SCF or M-CSF with IL-3 or GM-CSF in FDC-P1 cells: a sensitive assay of transforming mutations of c-fms.Semantic proximity Read ↗

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.Semantic proximity Read ↗

Macrophage-colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms/CSF-1 receptor cDNA.Semantic proximity Read ↗

Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line.Semantic proximity Read ↗

A C-terminal FMS mutation in a patient with B-cell malignancy.Semantic proximity Read ↗

Distinct classes of factor-independent mutants can be isolated after retroviral mutagenesis of a human myeloid stem cell line.Semantic proximity Read ↗

Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling.Semantic proximity Read ↗

Expression of a Y559F mutant CSF-1 receptor in M1 myeloid cells: a role for Src kinases in CSF-1 receptor-mediated differentiation.Semantic proximity Read ↗

A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.